Genetic variation in glutamatergic genes moderates the effects of childhood adversity on brain volume and IQ in treatment-resistant schizophrenia

Suriati Mohamed Saini; Chad A Bousman; Serafino G Mancuso; Vanessa Cropley; Tamsyn E Van Rheenen; Rhoshel K Lenroot; Jason Bruggemann; Cynthia S Weickert; Thomas W Weickert; Suresh Sundram; Ian P Everall; Christos Pantelis

Journal article

Genetic variation in glutamatergic genes moderates the effects of childhood adversity on brain volume and IQ in treatment-resistant schizophrenia

Suriati Mohamed Saini, Chad A Bousman, Serafino G Mancuso, Vanessa Cropley, Tamsyn E Van Rheenen, Rhoshel K Lenroot, Jason Bruggemann, Cynthia S Weickert, Thomas W Weickert, Suresh Sundram, Ian P Everall, Christos Pantelis

Schizophrenia | Nature Portfolio | Published : 2023

DOI: 10.1038/s41537-023-00381-w

University of Melbourne Researchers

Vanessa Cropley Author

Tamsyn van Rheenen Author

Christos Pantelis Author

Related Projects (3)

Using brain imaging to distinguish amongst subtypes of schizophrenia: An investigation of brain muscarinic receptors.

CHARACTERISING FACIAL EMOTION PROCESSING NETWORKS IN BIPOLAR DISORDER

This research will use cutting edge imaging methodologies to investigate brain connectivity in neural circuits involved in emotion processin..

NEUROBIOLOGICAL 'RISK' AND 'RESILIENCE' BIOMARKERS OF SEVERE MENTAL ILLNESS

Mental disorders of childhood (schizotypal disorder, autism spectrum disorders) and adolescence (psychoses, schizophrenia) represent a major..

Grants

Awarded by NHMRC (Enabling Grant)

Awarded by NHMRC

Awarded by National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship

Awarded by NHMRC L3 Investigator Grant

Awarded by NHMRC Early Career Fellowship

Awarded by Brain and Behavior Research Foundation (NARSAD) Young Investigator Award

Awarded by Publication Reward Grant

Funding Acknowledgements

Chief Investigators for ASRB were Carr, V., Schall, U., Scott, R., Jablensky, A., Mowry, B., Michie, P., Catts, S., Henskens, F., Pantelis, C. We thank Loughland, C., the ASRB Manager, and acknowledge the help of Jason Bridge for ASRB and Toni Meritt for CRC database queries. The Australian Schizophrenia Research Bank (ASRB) was supported by the NHMRC (Enabling Grant, ID 386500), the Pratt Foundation, the Ramsay Health Care, the Viertel Charitable Foundation and the Schizophrenia Research Institute. The CRC for Mental Health Psychosis (CRC) was supported by the NHMRC (MHREC ID 2012.069). S.M.S. was supported by the Publication Reward Grant (GP-K014766), the Ministry of Higher Education Malaysia Scholarship and the National University of Malaysia. C.P. was supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (IDs: 1105825), and NHMRC L3 Investigator Grant (1196508). C.A.B. was supported by the Alberta Children's Hospital Research Foundation and the University of Calgary Cumming School of Medicine. T.E.V.R. was supported by an NHMRC Early Career Fellowship (1088785). V.C. was supported by the NHMRC Early Career Fellowship (628880), a Brain and Behavior Research Foundation (NARSAD) Young Investigator Award (21660), and a University of Melbourne Faculty of Medicine, Dentistry, and Health Sciences Research Fellowship.